| Date | Location | Result | |
| 5/8/2021 | Greencastle, Ind. | WashU 4, DePauw University 3 | Box score |
| 5/8/2021 | Greencastle, Ind. | WashU 22, DePauw University 1 | Box score |
| May 2, 2021 | Delaware, Ohio, USA | Ohio Wesleyan 27, DePauw University 12 | Box score |
| May 1, 2021 | Delaware, Ohio, USA | DePauw University 11, Ohio Wesleyan 9 | Box score |
| May 1, 2021 | Delaware, Ohio, USA | DePauw University 5, Ohio Wesleyan 1 | Box score |
| 4/30/2021 | Greencastle, Ind. | Ohio Wesleyan 9, DePauw University 3 | Box score |
| 4/30/2021 | Greencastle, Ind. | DePauw University 10, Ohio Wesleyan 5 | Box score |
| 4/25/2021 | Granville, Ohio | Denison 13, DePauw University 3 | Box score |
| 4/25/2021 | Granville, Ohio | Denison 17, DePauw University 1 | Box score |
| 4/24/2021 | Granville, Ohio | Denison 13, DePauw University 4 | Box score |
| 4/22/2021 | Greencastle, Ind. | DePauw University 12, Denison 4 | Box score |
| 4/22/2021 | Greencastle, Ind. | DePauw University 5, Denison 2 | Box score |
| 4/18/2021 | Greencastle, Ind. | Wabash College 11, DePauw University 6 | Box score |
| 4/18/2021 | Greencastle, Ind. | Wabash College 4, DePauw University 3 | Box score |
| 4/17/2021 | Greencastle, Ind. | Wittenberg 11, DePauw University 0 | |
| 4/17/2021 | Greencastle, Ind. | Wittenberg 10, DePauw University 9 | Box score |
| 4/14/2021 | Springfield, OH | DePauw University 8, Wittenberg 0 | Box score |
| 4/14/2021 | Springfield, OH | DePauw University 4, Wittenberg 2 | Box score |
| 4/3/2021 | Crawfordsville, IN | Wabash College 8, DePauw University 7 | Box score |
| 4/3/2021 | Crawfordsville, IN | Wabash College 10, DePauw University 2 | Box score |
| 4/2/2021 | Greencastle, Ind. | DePauw University 5, Wabash College 3 | Box score |
| 4/2/2021 | Greencastle, Ind. | Wabash College 5, DePauw University 2 | Box score |
| Mar 27, 2021 | Naperville, Ill. | North Central 5, DePauw University 1 | Box score |
| Mar 21, 2021 | St. Louis, Mo. | WashU 9, DePauw University 4 | Box score |
| Mar 20, 2021 | St. Louis, Mo. | WashU 10, DePauw University 0 | Box score |
| Mar 20, 2021 | St. Louis, Mo. | WashU 12, DePauw University 1 | Box score |
| 3/14/2021 | Greencastle, Ind. | DePauw University 15, Concordia Chicago 13 | Box score |
| 3/14/2021 | Greencastle, Ind. | Concordia Chicago 9, DePauw University 6 | Box score |
| 3/13/2021 | Greencastle, Ind. | DePauw University 12, Concordia Chicago 11 | Box score |
| 3/13/2021 | Greencastle, Ind. | DePauw University 4, Concordia Chicago 2 | Box score |
| 3/9/2021 | Indianapolis, Ind. | Butler 16, DePauw University 4 | Box score |
| Mar 06, 2021 | Greenville, Ill. | DePauw University 8, Greenville 7 | Box score |
| Mar 06, 2021 | Greenville, Ill. | DePauw University 6, Greenville 3 | Box score |
| 3/5/2021 | Greencastle, Ind. | DePauw University 4, Greenville 1 | Box score |
| 2/28/2021 | Westfield, IN | DePauw University 17, Wabash 5 | Box score |
| 2/28/2021 | Westfield, IN | Wabash College 4, DePauw University 3 | Box score |